The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats.

Abstract

AIM The objective of the present study was to evaluate the protective effects of halofuginone against renal ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS Male Wistar albino rats were unilaterally nephrectomized and the left renal pedicles were occluded for 45 min to induce ischemia and then reperfused for 6 h (early) or for 72 h (late). The… (More)
DOI: 10.1016/j.jpurol.2012.01.015

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