The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth.

@article{Esposito2009TheAE,
  title={The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth.},
  author={Ciro Esposito and Bina Parrilla and Flavia Cornacchia and Fabrizio Grosjean and Filippo Mangione and Nicoletta Serpieri and Rossella Valentino and Luigi Villa and Mariarosa Arra and Vittoria Esposito and Antonio Dal Canton},
  journal={Growth factors},
  year={2009},
  volume={27 3},
  pages={173-80}
}
Although several reports suggest an antifibrogenic effect of hepatocyte growth factor (HGF), an increased deposition of matrix induced by HGF has also been reported. These conflicting effects could result from a diverse proliferative state of the target cells. Aim of the present study was to evaluate HGF effects on growth arrested (quiescent) and actively proliferating renal tubular epithelial (HK-2) cells. HK-2 cells were cultured in RPMI medium either on agarose gel or on plastic surface in… CONTINUE READING
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