The antifibrogenic effect of (−)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells

Abstract

Hepatic stellate cells (HSC) are the major players during hepatic fibrogenesis. Overproduction of extracellular matrix (ECM) is a characteristic of activated HSC. Transforming growth factor-beta (TGF-β) is the most potent fibrogenic cytokine while connective tissue growth factor (CTGF) mediates the production of TGF-β-induced ECM in activated HSC. HSC… (More)
DOI: 10.1038/labinvest.3700425

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