The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate.

@article{Frigerio2006TheAD,
  title={The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate.},
  author={Francesca Frigerio and Gaelle Chaffard and Monique Berwaer and Pierre Maechler},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 8},
  pages={965-73}
}
Topiramate (Topamax), primarily prescribed against epilepsy, was reported to reduce body weight and to ameliorate glycemic control in obese patients with diabetes. In rodent models of obesity and diabetes, topiramate treatment counteracts hyperglycemia and increases insulin levels upon glucose tolerance test. These observations suggest that topiramate might exert direct action on insulin secreting cells, in particular regarding obesity associated beta-cell dysfunction. In this study, INS-1E… CONTINUE READING
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