The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons.

@article{Gebhardt2001TheAD,
  title={The antiepileptic drug losigamone decreases the persistent Na+ current in rat hippocampal neurons.},
  author={Christine Gebhardt and Joerg Breustedt and Michael Noeldner and Shyam Sunder Chatterjee and Uwe F Heinemann},
  journal={Brain research},
  year={2001},
  volume={920 1-2},
  pages={27-31}
}
The tetronic acid derivative losigamone is a new anticonvulsant drug with a mechanism of action that was previously unknown. The drug decreases the frequency of spontaneous action potentials and suppresses repetitive firing of neurons. Here we tested the hypothesis that losigamone suppresses the persistent Na+ current (I(NaP)) in hippocampal neurons of rat brain slices and in cultured hippocampal neurons. Whole-cell voltage clamp recordings from neurons of juvenile rats (P15-P25) were performed… CONTINUE READING