The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation.

@article{Palma2007TheAD,
  title={The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation.},
  author={Eleonora Palma and Davide Ragozzino and Silvia Di Angelantonio and Addolorata Mascia and Francesca Maiolino and Mario Manfredi and Giampaolo Cantore and Vincenzo Esposito and Giancarlo Di Gennaro and Pierpaolo Quarato and Ricardo Miledi and Fabrizio Eusebi},
  journal={Epilepsia},
  year={2007},
  volume={48 10},
  pages={1842-9}
}
PURPOSE GABAA receptors from the brain of patients afflicted with mesial temporal lobe epilepsy (MTLE) become less efficient (run-down) when repetitively activated by GABA. Experiments were designed to investigate whether the antiepileptic drug, levetiracetam (LEV), which is used as an adjunctive treatment for medically intractable MTLE, counteracts the GABAA receptor run-down. METHODS GABAA receptors were microtransplanted from the brains of patients afflicted with MTLE into Xenopus oocytes… CONTINUE READING

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