The antidiabetic gutsy role of metformin uncovered?

@article{Burcelin2013TheAG,
  title={The antidiabetic gutsy role of metformin uncovered?},
  author={R{\'e}my Burcelin},
  journal={Gut},
  year={2013},
  volume={63},
  pages={706 - 707}
}
Why are grams of metformin recommended to lower hyperglycaemia in type 2 diabetic patients whereas the dose ranges from micrograms to milligrams for all other antidiabetic agents? Why is that 50% of the patients should discontinue or reduce the daily therapeutic doses to avoid diarrhoea? Why has the previously established mode of action of metformin been continuously disputed and re-evaluated by the scientific community? To these questions, Shin et al 1 shifted again the paradigm related to… 

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