The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.

  title={The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.},
  author={Kyoung-Tae Lee and Tae Woo Jung and Hak-ju Lee and Seul-Gi Kim and Yu-Su Shin and Wan-Kyunn Whang},
  journal={Archives of pharmacal research},
  volume={34 7},
Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis… CONTINUE READING


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