The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR gamma and CBP.

@article{Mizukami1997TheAA,
  title={The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR gamma and CBP.},
  author={Junko Mizukami and Taizo Taniguchi},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={240 1},
  pages={61-4}
}
The peroxisome proliferator-activated receptor (PPAR) gamma is a member of the nuclear hormone receptor family, which is predominantly expressed on adipocytes and considered to be involved in the process of adipogenesis. The new thiazolidinedione (TZD) compound, T-174, developed as an antidiabetic drug, stimulated the transcription of PPAR gamma and the adipocyte differentiation of 3T3-L1 cells. Interestingly, T-174 induced the interaction between PPAR gamma and CBP (cAMP response element… CONTINUE READING

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