The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive steroid and monoamine levels

@article{Espallergues2012TheAE,
  title={The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive steroid and monoamine levels},
  author={J. Espallergues and T. Mamiya and M. Vall{\'e}e and T. Koseki and T. Maurice},
  journal={Neuropharmacology},
  year={2012},
  volume={62},
  pages={492-502}
}
  • J. Espallergues, T. Mamiya, +2 authors T. Maurice
  • Published 2012
  • Chemistry, Medicine
  • Neuropharmacology
  • In the present study, we analyzed the effects of a systemic treatment with the competitive 3β-hydroxysteroid dehydrogenase (3β-HSD) inhibitor trilostane on: (i) neurosteroid and monoamine levels in the brain, and (ii) the antidepressant activity of steroids and antidepressants in the forced swimming test (FST). 3β-HSD converts pregnenolone (PREG) into progesterone (PROG) or dehydroepiandrosterone (DHEA) into androstenedione. These neuroactive steroids are known to regulate neurotransmitters… CONTINUE READING
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