The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors.

Abstract

The FDA-approved antidepressant and smoking cessation drug bupropion is known to inhibit dopamine and norepinephrine reuptake transporters, as well as nicotinic acetylcholine receptors (nAChRs) which are cation-conducting members of the Cys-loop superfamily of ion channels, and more broadly pentameric ligand-gated ion channels (pLGICs). In the present study… (More)
DOI: 10.1016/j.neuropharm.2016.09.021

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