The antidepressant and antiinflammatory effects of rolipram in the central nervous system.

@article{Zhu2001TheAA,
  title={The antidepressant and antiinflammatory effects of rolipram in the central nervous system.},
  author={J Zhu and Eilhard Mix and Bengt Winblad},
  journal={CNS drug reviews},
  year={2001},
  volume={7 4},
  pages={
          387-98
        }
}
Rolipram is a selective inhibitor of phosphodiesterases (PDE) IV, especially of the subtype PDE IVB. These phosphodiesterases are responsible for hydrolysis of the cyclic nucleotides cAMP and cGMP, particularly in nerve and immune cells. Consequences of rolipram-induced elevation of intracellular cAMP are increased synthesis and release of norepinephrine, which enhance central noradrenergic transmission, and suppress expression of proinflammatory cytokines and other mediators of inflammation… CONTINUE READING

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