The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors.

@article{Szot2004TheAA,
  title={The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors.},
  author={Patricia Szot and M. T. Lester and Marc L Laughlin and Richard D Palmiter and Larry Cameron Liles and David Weinshenker},
  journal={Neuroscience},
  year={2004},
  volume={126 3},
  pages={795-803}
}
The alpha2-adrenoreceptor (AR) is the most investigated noradrenergic receptor with regard to modulation of seizure activity. However, because of the complexity of multiple alpha2-AR subtypes and their distribution, the exact role of this receptor in modulating seizure activity is not clear. alpha2A- and alpha2C-ARs function as both autoreceptors (presynaptic) on noradrenergic neurons, where they regulate norepinephrine (NE) release, and as postsynaptic receptors on neurons that receive… CONTINUE READING

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