The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

@article{Wong1986TheAM,
  title={The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.},
  author={E. Wong and J. Kemp and T. Priestley and A. R. Knight and G. Woodruff and L. Iversen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 18},
  pages={
          7104-8
        }
}
  • E. Wong, J. Kemp, +3 authors L. Iversen
  • Published 1986
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.7 nM) binding sites for [3H]MK-801 in rat brain membranes. These sites are heat-labile, stereoselective, and regionally specific, with the hippocampus showing the highest density of sites, followed by cerebral cortex, corpus striatum, and… Expand
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  • Proc . Nati . Acad . Sci . USA
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