The anticancer drug cytarabine does not interact with the human erythrocyte membrane.

@article{Suwalsky2003TheAD,
  title={The anticancer drug cytarabine does not interact with the human erythrocyte membrane.},
  author={Mario Suwalsky and Pedro L{\'o}pez Hern{\'a}ndez and Fernando Pardo-Manual de Villena and Carlos Patricio Sotomayor},
  journal={Zeitschrift fur Naturforschung. C, Journal of biosciences},
  year={2003},
  volume={58 11-12},
  pages={885-90}
}
Cytarabine, an analog of deoxycytidine, is an important agent in the treatment of ovarian carcinoma, acute myeloid and lymphoblastic leukemia. Its mechanism of action has been attributed to an interference with DNA replication. The plasma membrane has received increasing attention as a possible target of antitumor drugs, where the drugs may act as growth factor antagonists and receptor blockers, interfere with mitogenic signal transduction or exert direct cytotoxic effects. Furthermore, it has… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 14 references

Chemical control of K 562 cells exposed to the anticancer drug adriamycin . phospholipid distribution across bilayer membranes

  • M. BoonJ., D. SmithB.
  • Res . Commun . Mol . Pathol . Pharmacol .
  • 2002

Acute cerebellar of 1 -  - d - arabinofuranosylcytosine in human ovarian syndrome following intermediate - dose cytarabine . adenocarcinoma cells

  • K. Marsot
  • Cancer Res .
  • 2001
1 Excerpt

Cytarabine - induced aseptic meningitis

  • P. JamiesonG., B. SnookM., R. BradleyT.
  • Bertoncello Leukemia
  • 2001

High - dose cytarabine - based ther - dijk J . , and

  • G. Speelmans, M. StaffhorstR.W.H., K. Versluis, J. Ree-FeldmanE.
  • 2000

Cisplatin complexes apy in adults with acute lymphoblastic leukemia . with phosphatidylserine in membranes

  • B. deKruijff
  • Biochemistry Leuk . Res .
  • 1997

Maintenance mains and dynamics as detected by Laurdan fluores - and consequences of membrane phospholipid asym - cence

  • F. DevauxP., A. Zachowsky
  • J . Fluorescence
  • 1994

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