The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase.


We recently reported that the antineoplastic thiodioxopiperazine natural product chaetocin potently induces cellular oxidative stress, thus selectively killing cancer cells. In pursuit of underlying molecular mechanisms, we now report that chaetocin is a competitive and selective substrate for the oxidative stress mitigation enzyme thioredoxin reductase-1… (More)
DOI: 10.1089/ARS.2008.2318