The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

  title={The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease},
  author={Jeff Sevigny and Ping Chiao and Thierry Bussi{\`e}re and Paul H Weinreb and Leslie H. Williams and Marcel Maier and Robert Dunstan and Stephen P. Salloway and Tianle Chen and Yan Ling and John O’Gorman and Fang Qian and Mahin F Arastu and Mingwei Li and Sowmya Chollate and Melanie S. Brennan and Omar Quintero-Monzon and Robert H. Scannevin and H. Moore Arnold and Thomas Engber and Kenneth J. Rhodes and J. L. Ferrero and Yaming Hang and Alvydas Mikulskis and Jan Grimm and C. Hock and Roger M. Nitsch and Alfred Sandrock},
Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we report the generation of aducanumab, a human monoclonal antibody that selectively targets aggregated Aβ. In a transgenic mouse model of AD, aducanumab is shown to enter the brain… CONTINUE READING
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