The antibiotic resistome: challenge and opportunity for therapeutic intervention.

@article{Martnez2012TheAR,
  title={The antibiotic resistome: challenge and opportunity for therapeutic intervention.},
  author={Jos{\'e} L Mart{\'i}nez},
  journal={Future medicinal chemistry},
  year={2012},
  volume={4 3},
  pages={347-59}
}
Despite the relevance of infectious disease as main causes of human morbidity and mortality, the development of new antibacterials is not among the highest priorities for pharmaceutical companies. Regulatory and economic issues, together with the lack of novel targets, might justify the reduced rate of discovery of new antimicrobials. With the increasing number of antibiotic resistant pathogens, the mechanisms of resistance appear as appealing alternatives for developing new drugs. Defining the… CONTINUE READING