The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.

Abstract

The mammalian intestine is home to ~100 trillion bacteria that perform important metabolic functions for their hosts. The proximity of vast numbers of bacteria to host intestinal tissues raises the question of how symbiotic host-bacterial relationships are maintained without eliciting potentially harmful immune responses. Here, we show that RegIIIγ, a… (More)
DOI: 10.1126/science.1209791

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