The antiatherogenic and antiinflammatory effect of HDL–associated lysosphingolipids operates via Akt ➞NF–kappaB signalling pathways in human vascular endothelial cells

@article{Schmidt2005TheAA,
  title={The antiatherogenic and antiinflammatory effect of HDL–associated lysosphingolipids operates via Akt ➞NF–kappaB signalling pathways in human vascular endothelial cells},
  author={Priv.-Doz. Dr. A. Schmidt and Sven Geigenmueller and Wolfgang Voelker and Eckhart Buddecke},
  journal={Basic Research in Cardiology},
  year={2005},
  volume={101},
  pages={109-116}
}
Adhesion of mononuclear cells to the vascular endothelium and their subsequent transmigration into the arterial wall represent key events in the pathogenesis of arteriosclerosis. In previous studies we have shown that high density lipoproteins (HDL) and the HDL–associated sphingosylphosphorylcholine (SPC) have the ability to suppress the TNF–alpha–induced expression of endothelial cell E–selectin. However, the current understanding of the mechanism by which HDL reduces the expression of E… CONTINUE READING
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High density lipoprotein associated lysosphingolipids reduce E - selectin expression in human endothelial cells

Nofer, S Geigenmüller, +3 authors A Schmidt
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