The antiarrhythmic peptide analog ZP123 prevents atrial conduction slowing during metabolic stress.

@article{Haugan2005TheAP,
  title={The antiarrhythmic peptide analog ZP123 prevents atrial conduction slowing during metabolic stress.},
  author={Ketil Haugan and Kristine Boisen Olsen and Line Hartvig and J\orgen S\oberg Petersen and Niels-Henrik Holstein-Rathlou and James K. Hennan and Morten Schak Nielsen},
  journal={Journal of cardiovascular electrophysiology},
  year={2005},
  volume={16 5},
  pages={537-45}
}
OBJECTIVE As atrial conduction slowing is important in the pathogenesis of atrial reentry arrhythmias, a drug that increases atrial conduction or prevents atrial conduction slowing could serve to prevent atrial reentry arrhythmias. In this study, we investigated whether the novel stable antiarrhythmic peptide analog, ZP123, was able to prevent atrial conduction slowing. METHODS We examined the effect of ZP123 on metabolic stress-induced changes in conduction velocity (CV) and on dynamic CV… CONTINUE READING

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ZP123 prevents 18aglycyrrhetinic acid-induced inhibition of cAMP transfer

L Hartvig, KN Christjansen, J Hyttel, JS Petersen
Acta Physiol Scand 2004;181:A109 • 2004

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