The antiarrhythmic action of ischaemic preconditioning in rat hearts does not involve functional Gi proteins.

@article{Lawson1993TheAA,
  title={The antiarrhythmic action of ischaemic preconditioning in rat hearts does not involve functional Gi proteins.},
  author={Clive S Lawson and D. J. Coltart and David J. Hearse},
  journal={Cardiovascular research},
  year={1993},
  volume={27 4},
  pages={681-7}
}
OBJECTIVE Ischaemic preconditioning has been reported to be mediated by inhibitory G (Gi) proteins in rabbits; however, the mechanism of preconditioning in rats appears to differ from that in other species. The aim of this study was to determine whether functional Gi proteins are required for the antiarrhythmic action of preconditioning in rats. METHODS Donor rats were randomised to receive pertussis toxin (25 micrograms.kg-1 intravenously) or saline. After 48 h the hearts were isolated and… CONTINUE READING

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