The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.

@article{Wang1999TheAG,
  title={The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.},
  author={J M Wang and Jennifer R Chao and Weiqin Chen and Min Liang Kuo and Jeffrey Jong-Young Yen and H. F. Yang-Yen},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 9},
  pages={6195-206}
}
mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) signaling pathways and plays an important role in the viability response of these cytokines. In this study, we demonstrated that cytokine stimulation of mcl-1 mRNA and protein expression were attenuated by pretreatment of cells with phosphatidylinositol 3-kinase (PI3-K) inhibitors. Reporter gene assays further showed that the PI3-K/Akt signaling pathway was… CONTINUE READING
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Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research • 2001
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