The antiapoptotic effect of granulocyte colony-stimulating factor reduces infarct size and prevents heart failure development in rats.

@article{Baldo2011TheAE,
  title={The antiapoptotic effect of granulocyte colony-stimulating factor reduces infarct size and prevents heart failure development in rats.},
  author={Marcelo Perim Baldo and Ana Paula Couto Davel and Danilo M Damas-Souza and Jos{\'e} Edgar Nicoletti-Carvalho and Silvana Auxiliadora Bordin and Hernandes F Carvalho and S{\'e}rgio Lam{\^e}go Rodrigues and Luciana V Rossoni and Jos{\'e} Geraldo Mill},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2011},
  volume={28 1},
  pages={33-40}
}
BACKGROUND/AIM Granulocyte colony-stimulating factor (G-CSF) reduces myocardial injury and improves cardiac function after myocardial infarction (MI). We investigated the early alterations provided by G-CSF and the chronic repercussions in infarcted rats. METHODS Male Wistar rats (200-250g) received vehicle (MI) or G-CSF (MI-GCSF) (50 μg/kg, sc) at 7, 3 and 1 days before MI surgery. Afterwards MI was produced and infarct size was measured 1 and 15 days after surgery. Expression of anti- and… CONTINUE READING

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