The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice.

@article{Sunamura2000TheAE,
  title={The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice.},
  author={Makoto Sunamura and Lulu Sun and Lucian Lozonschi and Dan G Duda and Takahide Kodama and Gaku Matsumoto and Hiromune Shimamura and Kiyoshi Takeda and Masahiro Kobari and Hirofumi Hamada and Seiki Matsuno},
  journal={Pancreas},
  year={2000},
  volume={20 3},
  pages={
          227-33
        }
}
Interleukin 12 (IL-12) is a heterodimeric cytokine that exerts a potent antitumor effect through its pleiotropic actions. It was recently reported that IL-12 has also a potent antiangiogenic effect through the induction of IFN-gamma, which triggers the production of chemokines such as IP-10 that has been shown to have antiangiogenesis properties. In this study we transfected the IL-12 gene into a human pancreatic adenocarcinoma cell line (PK-1). PK-1 cells transfected with the green… CONTINUE READING
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