The anti-viral factor APOBEC3G enhances natural killer cell recognition of HIV-infected primary T cells

@inproceedings{Norman2011TheAF,
  title={The anti-viral factor APOBEC3G enhances natural killer cell recognition of HIV-infected primary T cells},
  author={Jason M. Norman and Michael K. Mashiba and Lucy A. McNamara and Adewunmi A Onafuwa-Nuga and Estelle Chiari-Fort and Wenwen Shen and Kathleen L Collins},
  booktitle={Nature Immunology},
  year={2011}
}
APOBEC3G (A3G) is an intrinsic antiviral factor that inhibits the replication of human immunodeficiency virus (HIV) by deaminating cytidine residues to uridine. This causes guanosine-to-adenosine hypermutation in the opposite strand and results in inactivation of the virus. HIV counteracts A3G through the activity of viral infectivity factor (Vif), which promotes degradation of A3G. We report that viral protein R (Vpr), which interacts with a uracil glycosylase, also counteracted A3G by… CONTINUE READING