The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

  title={The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis},
  author={Stephen H Patterson and Susan Wyllie and Suzanne Norval and Laste Stojanovski and Frederick R. C. Simeons and Jennifer L Auer and Maria Osuna-Cabello and Kevin D Read and Alan H. Fairlamb},
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania donovani both in vitro and in vivo. Twice-daily oral dosing of delamanid at 30 mg kg(-1) for 5 days resulted in sterile cures in a mouse model of VL. Treatment with lower doses revealed a U-shaped (hormetic) dose-response curve with greater… CONTINUE READING
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