The anti-thrombotic activity of surfactins.

  title={The anti-thrombotic activity of surfactins.},
  author={Jong-Hwan Lim and B. Park and M. Kim and Mi-Hyun Hwang and M. Rhee and S. Park and H. Yun},
  journal={Journal of veterinary science},
  volume={6 4},
  • Jong-Hwan Lim, B. Park, +4 authors H. Yun
  • Published 2005
  • Chemistry, Medicine
  • Journal of veterinary science
  • Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents. 
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