The anti-schistosomal drug praziquantel is an adenosine antagonist

@article{Angelucci2007TheAD,
  title={The anti-schistosomal drug praziquantel is an adenosine antagonist},
  author={F. Angelucci and A. Basso and A. Bellelli and M. Brunori and L. Pica Mattoccia and C. Valle},
  journal={Parasitology},
  year={2007},
  volume={134},
  pages={1215 - 1221}
}
SUMMARY The mechanism of action of praziquantel (PZQ), the drug of choice against schistosomiasis, is still unclear. Since exposure of schistosomes to the drug is associated with calcium influx and muscular contraction, calcium channels have been suggested as the target, although direct combination of PZQ with their subunits was never demonstrated. We report a hitherto unknown effect of PZQ, namely the inhibition of nucleoside uptake, as observed in living worms using radio-isotope labelled… Expand
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