The anti-reflux barrier and mechanisms of gastro-oesophageal reflux.

@article{Holloway2000TheAB,
  title={The anti-reflux barrier and mechanisms of gastro-oesophageal reflux.},
  author={Richard H. Holloway},
  journal={Bailliere's best practice & research. Clinical gastroenterology},
  year={2000},
  volume={14 5},
  pages={681-99}
}
The lower oesophageal sphincter (LOS) is the major component of the anti-reflux barrier. The majority of reflux episodes occur because of intermittent brief complete lower oesophageal sphincter relaxations, transient LOS relaxations, rather than from chronic absence of LOS pressure. Recent advances in the understanding of the neural mechanisms and the… CONTINUE READING