The anti-proliferative effect of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b) pyran is potentiated via induction of estrogen receptor beta and p21 in human endometrial adenocarcinoma cells.

@article{Fatima2013TheAE,
  title={The anti-proliferative effect of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b) pyran is potentiated via induction of estrogen receptor beta and p21 in human endometrial adenocarcinoma cells.},
  author={Iram Fatima and Ruchi Saxena and Geetika Kharkwal and Mohammad Kamil Hussain and Neelu Yadav and Kanchan Hajela and Pushp Lata Sankhwar and Anila Dwivedi},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2013},
  volume={138},
  pages={123-31}
}
In an effort to develop novel therapeutic agents for endometrial cancer, benzopyran derivatives synthesized at our institute display significant inhibitory activity on cellular growth in uterine cancer cells. The current study was undertaken to demonstrate and explore the estrogen receptor (ER) subtype mediated mechanism of action of benzopyran derivative 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b) pyran (K-1) in human endometrial cancer cells. K-1 competitively inhibited the… CONTINUE READING