The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.

@article{Wang2009TheAD,
  title={The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.},
  author={Ying Wang and Robyn Branicky and Zaruhi Stepanyan and Melissa Carroll and M Guimond and Abdelmadjid K Hihi and Steve Hayes and Kevin McBride and Siegfried Hekimi},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 1},
  pages={314-23}
}
The development of neurodegenerative diseases such as Alzheimer, Parkinson, and Huntington disease is strongly age-dependent. Discovering drugs that act on the high rate of aging in older individuals could be a means of combating these diseases. Reduction of the activity of the mitochondrial enzyme CLK-1 (also known as COQ7) slows down aging in Caenorhabditis elegans and in mice. Clioquinol is a metal chelator that has beneficial effects in several cellular and animal models of… CONTINUE READING
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