Corpus ID: 20141477

The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.

@article{Gadangi1996TheAM,
  title={The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.},
  author={Pratap Gadangi and M Longaker and Dwight Naime and Richard I. Levin and Phoebe A. Recht and Mar{\'i}a Carmen Montesinos and M T Buckley and G Carlin and B N Cronstein},
  journal={Journal of immunology},
  year={1996},
  volume={156 5},
  pages={
          1937-41
        }
}
The anti-inflammatory mechanism of sulfasalazine is not well understood. It has recently been shown that sulfasalazine inhibits 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase, an enzyme involved in de novo purine biosynthesis. We recently demonstrated that methotrexate promotes intracellular AICAR accumulation, thereby increasing adenosine release and diminishing inflammation, so we tested the hypothesis that sulfasalazine similarly promotes intracellular AICAR accumulation… Expand
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