The anti-inflammatory effect of exercise.

@article{Petersen2005TheAE,
  title={The anti-inflammatory effect of exercise.},
  author={Anne Marie Winther Petersen and Bente Klarlund Pedersen},
  journal={Journal of applied physiology},
  year={2005},
  volume={98 4},
  pages={
          1154-62
        }
}
Regular exercise offers protection against all-cause mortality, primarily by protection against cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been associated with chronic low-grade systemic inflammation reflected by a two- to threefold elevated level of several cytokines. Adipose tissue contributes to the production of TNF-alpha, which is reflected by elevated levels of soluble TNF-alpha receptors, IL-6, IL-1 receptor antagonist, and C-reactive protein. We… Expand
The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control.
TLDR
IL-6 was introduced as the first myokine, defined as a cytokine, that is produced and released by contracting skeletal muscle fibres, exerting its effects in other organs of the body, which may be involved in mediating the beneficial health effects against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases. Expand
The role of IL-6 in mediating the anti-inflammatory effects of exercise.
  • A. M. Petersen, B. Pedersen
  • Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2006
TLDR
This review focuses on the anti-inflammatory effects of Exercise and how this may contribute to mediate the beneficial health effects of exercise training in patients with chronic diseases associated with chronic low-grade inflammation. Expand
Targeting Inflammation Through a Physical Active Lifestyle and Pharmaceuticals for the Treatment of Type 2 Diabetes
TLDR
While waiting for the outcome of long-term clinical pharmacological trials, it should be emphasized that physical activity represents a natural strong anti-inflammatory intervention with little or no side effects. Expand
The effects of chronic exercise on the inflammatory cytokines interleukin-6 and tumor necrosis factor-α are different with age.
  • M. Moon, Bongjun Cho, +5 authors H. Jang
  • Biology, Medicine
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2012
TLDR
It is suggested that chronic endurance exercise could influence the inflammatory response of hepatic tissues, as well as muscle, and that the effects of chronic endurance Exercise on inflammatory cytokine levels are different between old and young rats and an exercise program tailored for old subjects will be needed to obtain beneficial anti-inflammatory effects from exercise. Expand
The major inflammatory mediator interleukin-6 and obesity
TLDR
This paper reviews the studies describing elevatedIL-6 levels in obese patients and the role of adipocytes and adipose-tissue macrophages in the production of IL-6 and the effect on metabolism through several mechanisms, including adipose tissue-specific gene expression, triglyceride release, lipoprotein lipase downregulation, insulin sensitivity, and so on. Expand
Exercise-induced changes in inflammatory processes: Implications for thrombogenesis in cardiovascular disease
TLDR
An overview of the impact of different modes and intensities of physical activity on vascular inflammation and thrombogenesis is provided. Expand
Evidence for anti-inflammatory effects of exercise in CKD.
TLDR
Findings provide compelling evidence that walking exercise is safe with regard to immune and inflammatory responses and has the potential to be an effective anti-inflammatory therapy in predialysis CKD. Expand
Anti-Inflammatory Effect of Exercise Mediated by Toll-Like Receptor Regulation in Innate Immune Cells – A Review
TLDR
The aim of the present study is to review the current evidence about the anti-inflammatory effects of exercise and toll-like receptors regulation on immune cells in humans to contribute to the protective effect of exercise against insulin resistance and the prevention of the development of metabolic diseases. Expand
Effects of physical exercise on inflammatory markers of atherosclerosis.
TLDR
Analysis of available researches seem to confirm the efficacy of regular physical training as a nonpharmacological therapy having target chronic low-grade inflammation. Expand
Anti-inflammatory Effects of Exercise
TLDR
The anti-inflammatory effects of regular exercise may be mediated via a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti- inflammatory environment with each bout of exercise. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 185 REFERENCES
Inflammation: the link between insulin resistance, obesity and diabetes.
TLDR
The increased concentrations of TNF-alpha and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction, which might interfering with the anti-inflammatory effect of insulin, which in turn might promote inflammation. Expand
Role of Cytokines in Inducing Hyperlipidemia
TLDR
It can be postulated that lipoproteins are part of a nonspecific immune response stimulated by cytokines, the hormones of the immune systems, that can decrease the toxicity of harmful biological and chemical agents. Expand
Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity.
Fat tissue is a significant source of endogenous tumor necrosis factor alpha (TNFalpha), the pluripotent cytokine that plays an important role as a mediator of the peripheral insulin resistance foundExpand
Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis.
TLDR
TNF neutralisation with monoclonal anti-TNF antibodies increased HDL-cholesterol levels and decreased CRP and IL6 levels after 2 weeks, suggesting this treatment may improve the cardiovascular risk profile of patients with RA. Expand
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo.
TLDR
This is the first study to demonstrate that inflammatory cytokines IL-6 and IL-10 alter hepatic and skeletal muscle insulin action in vivo, and the mechanism may involve cytokine-induced alteration in intracellular fat contents. Expand
The cytokine response to strenuous exercise.
TLDR
The time course of cytokine production, the close association with muscle damage, and the finding of mRNA-IL-6 in skeletal muscle biopsies after intense exercise all support the idea that during eccentric exercise myofibers are mechanically damaged and that this process stimulates the local production of inflammatory cytokines. Expand
Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans
TLDR
Results suggested that exercise-induced pathogenesis including previously reported immunosuppression and neutrophil hyper-reactivity might be attributed, at least partly, to the systemic dynamics of the above bioactive substances. Expand
Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70.
TLDR
IL-12 p40 was present in excess of p70 especially after exercise, which may be one of the mechanisms behind several phenomena including cellular immunosuppression, an increase in the relative proportion of type-2 cytokines following exhaustive exercise, and the higher incidence of infections and allergic disorders in regularly exercising endurance athletes. Expand
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha.
  • C. Bruce, D. Dyck
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
  • 2004
TLDR
IL-6 plays an important role in regulating fat metabolism in muscle, increasing rates of FA oxidation, and attenuating insulin's lipogenic effects, which may be involved in the development of TNF-alpha-induced insulin resistance in skeletal muscle. Expand
Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans
TLDR
Physical exercise and rhIL‐6 infusion at physiological concentrations inhibit endotoxin‐induced TNF‐α production in humans and suggest that the mechanism include IL‐6, which is produced by and released from exercising muscles. Expand
...
1
2
3
4
5
...