The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ*

@article{Siddiqui2006TheAE,
  title={The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-$\gamma$*},
  author={Aqeel M Siddiqui and Xiaoxuan Cui and Rongqian Wu and Weifeng Dong and Mian Zhou and Maowen Hu and H. Hank Simms and Ping Wang},
  journal={Critical Care Medicine},
  year={2006},
  volume={34},
  pages={1874-1882}
}
Objective:Although phytochemical curcumin has been shown to possess anti-inflammatory properties, it remains unknown whether this agent has any beneficial effects in sepsis. The purpose of this study was to demonstrate whether curcumin protects septic animals and, if so, whether activation of peroxisome proliferator-activated receptor (PPAR)-γ, an anti-inflammatory nuclear receptor, plays any role. Design:Prospective, controlled, and randomized animal study. Setting:A research institute… 
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