The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

@inproceedings{Coutinho2011TheAA,
  title={The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights},
  author={Agnes E. Coutinho and Karen E. Chapman},
  booktitle={Molecular and Cellular Endocrinology},
  year={2011}
}
Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-inflammatory effects, they have been amongst the most widely used and effective treatments to control inflammatory and autoimmune diseases. However, their clinical efficacy is compromised by the metabolic effects of long-term treatment, which include osteoporosis, hypertension, dyslipidaemia and insulin resistance/type 2 diabetes mellitus. In recent years, a great deal of effort has been invested in… CONTINUE READING
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