The anti-human leukocyte antigen-DR monoclonal antibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice.

@article{CarloStella2006TheAL,
  title={The anti-human leukocyte antigen-DR monoclonal antibody 1D09C3 activates the mitochondrial cell death pathway and exerts a potent antitumor activity in lymphoma-bearing nonobese diabetic/severe combined immunodeficient mice.},
  author={C. Carlo-Stella and M. Di Nicola and M. Turco and L. Cleris and C. Lavazza and P. Longoni and M. Milanesi and M. Magni and M. Ammirante and A. Leone and Z. Nagy and W. Gioffr{\`e} and F. Formelli and A. Gianni},
  journal={Cancer research},
  year={2006},
  volume={66 3},
  pages={
          1799-808
        }
}
The fully human anti-HLA-DR antibody 1D09C3 has been shown to delay lymphoma cell growth in severe combined immunodeficient (SCID) mice. The present study was aimed at (a) investigating the mechanism(s) of 1D09C3-induced cell death and (b) further exploring the therapeutic efficacy of 1D09C3 in nonobese diabetic (NOD)/SCID mice. The chronic lymphocytic leukemia cell line JVM-2 and the mantle cell lymphoma cell line GRANTA-519 were used. Generation of reactive oxygen species (ROS) and… Expand
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