The anti-epileptic effect of 3-aminopropylarsonate on electrically-kindled and N-methyl-d-aspartate-kindled amygdala

  title={The anti-epileptic effect of 3-aminopropylarsonate on electrically-kindled and N-methyl-d-aspartate-kindled amygdala},
  author={Abdul-Salam Abdul-Ghani and Philip J. E. Attwell and Henry F. Bradford},
  journal={Brain Research},
The effects of 3-aminopropylarsonate, an arsono analogue of GABA, was tested on the development of electrically-kindled amygdala and on the expression of generalized seizure activity in electrically and NMDA fully amygdala-kindled rats. Intra-amygdaloid microinjection of 3-aminopropylarsonate (10 nmol in 0.5 microl injection vehicle) inhibited electrical epileptogenesis by keeping the seizure score at or below stage 1 on the Racine scale, and the afterdischarge duration (ADD) at or below 19.70… 
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Role of the N-methyl-d-aspartate-type receptors in the development and maintenance of hippocampal kindling in rats
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Anti-seizure and anti-epileptogenic effect of γ-vinyl γ-aminobutyric acid in amygdaloid kindling
We examined the effects of systemic administration of γ-vinyl γ-aminobutyric acid (GVG), a γ-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or
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