The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Wnt inhibitors in normal and ovariectomised rats.

@article{Parveen2018TheAD,
  title={The anti-epileptic drugs valproate, carbamazepine and levetiracetam cause bone loss and modulate Wnt inhibitors in normal and ovariectomised rats.},
  author={Bushra Parveen and Ambrish Kumar Tiwari and Moon Jain and Subhashis Pal and Naibedya Chattopadhyay and Manjari Tripathi and Divya Vohora},
  journal={Bone},
  year={2018},
  volume={113},
  pages={
          57-67
        }
}

Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats.

The findings suggest that VPA affects the microarchitectural properties of the bone and the AEDs CBZ, ESL and LEV appear to have less adverse effects on bone biology and may be a better choice when treating patients with respect to bone health.

Carbamazepine, Sodium Valproate and Levetiracetam Modulate Wnt Inhibitors in Indian Women with Epilepsy

The modulation of two Wnt inhibitors, sclerostin and dickkopf-1, following AED therapy in Indian women with epilepsy are reported, and it is concluded that these drugs may compromise bone health through disturbance in Wnt signaling mechanisms.

Comparison between the effects of older versus newer generations of antiepileptic drugs on bone metabolism in adult Iraqi patients: an observational study

Epileptic individuals who had been on AEDs for more than two years had increased parathyroid hormone levels, which were boosted by the newer antiepileptic drug Levetiracetam.

An update on the problem of osteoporosis in people with epilepsy taking antiepileptic drugs

Evidence related to the deteriorating influence of AEDs on bone, demonstrating generally stronger negative effects of conventional AED’s, is discussed.

Perspectives of personalized approach to prevention and treatment of anticonvulsant-induced osteoporosis via action on vitamin D exchange and VDR expression

Genetic association studies of VDR gene SNVs are important for understanding the genetic predictors of AIO and chronic back pain in patients with epilepsy, as well as for developing new personalized pharmacotherapy strategies.

Comparison between the effects of older versus newer generations of antiepileptic drugs on bone metabolism in adult Iraqi patients: an observational study [version 1; peer review: awaiting peer review]

Investigation of the effects of chronic use of older compared to the newer generations of antiepileptic drugs on bone metabolism-related biomarkers found that the median value of serum parathyroid hormone levels was significantly elevated in the epileptic patients' groupsCompared to the healthy control group, and calcium levels appear to be linked to greater ALP and low vitamin D levels.

The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C ) mice

The data, showing the negative impact of CBZ treatment on the developing mouse bones, raise important issues which must be considered in any human clinical applications ofCBZ in growing individuals.

Clinical efficacy and safety of the combined use of sodium valproate and levetiracetam in epilepsy children

The combined use of Levetiracetam and VPA could decrease inflammatory response and multiple organ impairment, and ameliorate bone metabolism of epilepsy children, and shows better safety profile and worth recommendation for more clinical applications.

Histological and immunohistochemical study on the effect of valporic acid on the bone of adult male guinea pigs and the possible protective role of L-carnitine

Administration of L-carnitine with valporic acid in guinea pigs has ameliorating effect on the histological abnormalities of bone, and therefore, L- c Carnitine could be prescribed for epileptic patients with VPA.

References

SHOWING 1-10 OF 48 REFERENCES

Effects of the Antiepileptic Drugs Phenytoin, Gabapentin, and Levetiracetam on Bone Strength, Bone Mass, and Bone Turnover in Rats.

The data suggested that gabapentin induced the rarefaction of cancellous bone, which was associated with decreased bone formation and enhanced bone resorption, and may affect bone strength and BMD after chronic exposure.

Raloxifene preserves phenytoin and sodium valproate induced bone loss by modulating serum estradiol and TGF-β3 content in bone of female mice.

The problem of osteoporosis in epileptic patients taking antiepileptic drugs

Bone problems may appear in both sexes during AED therapy, although women are additionally burdened with postmenopausal osteoporosis, and supplementation of vitamin D and calcium in patients on AEDs is recommended.

Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health

In conclusion, use of both levetiracetam and older AEDs was associated with bone loss over 1 year at clinically relevant fracture sites and a reduction in bone turnover.

Effects of carbamazepine on serum parathormone, 25- hydroxyvitamin D, bone specific alkaline phosphatase, C-telopeptide, and osteocalcin levels in healthy rats.

The main outcome of this prospective study in healthy rats showed no change in biochemical parameters of bone turnover during treatment with carbamazepine, and serum levels of 25-hydroxyvitamin D and parathormone and osteocalcin were found to be significantly higher in control group compared to isotonic saline solution group and carbsepine group.