The anti-cancer compound Schweinfurthin A targets Osh2 and disrupts lipid metabolism in the yeast model.

  title={The anti-cancer compound Schweinfurthin A targets Osh2 and disrupts lipid metabolism in the yeast model.},
  author={Behrooz Moosavi and Meng-Qi Gao and Xiao-Lei Zhu and Guangfu Yang},
  journal={Bioorganic chemistry},
Schweinfurthin A (Sch A) is a natural product with a selective and strong anti-cancer effect. Although it is known to target oxysterol binding proteins, the detailed mode of action is not well understood. Here, we provide strong evidence that yeast cells can be used as a eukaryotic model system to decipher the molecular modes of Sch A. We show that Sch A (100 µM) targets Osh2 (a yeast oxysterol binding protein homolog) genetically and taking advantage of computational chemistry indicate that… Expand
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