The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS.

@article{Szegedi2010TheAP,
  title={The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS.},
  author={Krisztina Szegedi and Enikő Sonkoly and Nikoletta Nagy and Istv{\'a}n Bal{\'a}zs N{\'e}meth and Zsuzsanna Bata-Cs{\"o}rgő and Lajos Kem{\'e}ny and Attila Dobozy and M{\'a}rta Sz{\'e}ll},
  journal={Experimental dermatology},
  year={2010},
  volume={19 3},
  pages={269-78}
}
Psoriasis Susceptibility-Related RNA Gene Induced by Stress (PRINS) is a non-coding RNA overexpressed in lesional and non-lesional psoriatic epidermis and induced by stress. Its function in healthy and psoriatic skin is still not known. Here, we report that PRINS regulates G1P3, a gene with anti-apoptotic effects in keratinocytes. siRNA-mediated inhibition of PRINS gene resulted in altered cell morphology and gene expression alterations, as demonstrated in a microarray experiment. One of the… CONTINUE READING

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