The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.

@article{Dzhagalov2008TheAB,
  title={The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.},
  author={Ivan Dzhagalov and Alexis Dunkle and Y. N. He},
  journal={Journal of immunology},
  year={2008},
  volume={181 1},
  pages={521-8}
}
T lymphocyte development and function are tightly regulated by the intrinsic death pathway through members of the Bcl-2 family. Genetic studies have demonstrated that the Bcl-2 family member Mcl-1 is an important anti-apoptotic protein in the development of multiple cell types including T lymphocytes. However, the expression pattern and anti-apoptotic roles of Mcl-1 in T lymphocytes at different developmental stages remain to be fully determined. In this study, we examined the expression… CONTINUE READING