The anti-angiogenic isoforms of VEGF in health and disease.

  title={The anti-angiogenic isoforms of VEGF in health and disease.},
  author={Yan Qiu and Coralie Hoareau-Aveilla and Sebastian Oltean and Steve Harper and David W Bates},
  journal={Biochemical Society transactions},
  volume={37 Pt 6},
Anti-angiogenic VEGF (vascular endothelial growth factor) isoforms, generated from differential splicing of exon 8, are widely expressed in normal human tissues but down-regulated in cancers and other pathologies associated with abnormal angiogenesis (cancer, diabetic retinopathy, retinal vein occlusion, the Denys-Drash syndrome and pre-eclampsia). Administration of recombinant VEGF(165)b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and… CONTINUE READING