The anti-angiogenic basis of metronomic chemotherapy

  title={The anti-angiogenic basis of metronomic chemotherapy},
  author={Robert S. Kerbel and Barton A. Kamen},
  journal={Nature Reviews Cancer},
In addition to proliferating cancer cells and various types of normal cells, such as those of the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the growing tumour vasculature. The anti-angiogenic efficacy of chemotherapy seems to be optimized by administering comparatively low doses of drug on a frequent or continuous schedule, with no extended interruptions — sometimes referred to as 'metronomic' chemotherapy. In addition to reduced acute toxicity, the… CONTINUE READING
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