The anti-HIV pseudopeptide HB-19 forms a complex with the cell-surface-expressed nucleolin independent of heparan sulfate proteoglycans.

@article{Nisole1999TheAP,
  title={The anti-HIV pseudopeptide HB-19 forms a complex with the cell-surface-expressed nucleolin independent of heparan sulfate proteoglycans.},
  author={S{\'e}bastien Nisole and Bernard Krust and Christian Callebaut and Gilles Guichard and Sylviane Muller and Jean Paul Briand and Ara G. Hovanessian},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 39},
  pages={27875-84}
}
The HB-19 pseudopeptide 5[Kpsi(CH(2)N)PR]-TASP, psi(CH(2)N) for reduced peptide bond, is a specific inhibitor of human immunodeficiency virus (HIV) infection in different CD4(+) cell lines and in primary T-lymphocytes and macrophages. Here, by using an experimental CD4(+) cell model to monitor HIV entry and infection, we demonstrate that HB-19 binds the cell surface and inhibits attachment of HIV particles to permissive cells. At concentrations that inhibit HIV attachment, HB-19 binds cells… CONTINUE READING

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