The anti-HIV pentameric pseudopeptide HB-19 binds the C-terminal end of nucleolin and prevents anchorage of virus particles in the plasma membrane of target cells.

@article{Nisole2002TheAP,
  title={The anti-HIV pentameric pseudopeptide HB-19 binds the C-terminal end of nucleolin and prevents anchorage of virus particles in the plasma membrane of target cells.},
  author={S{\'e}bastien Nisole and Elias Amine Said and Claudia C. Mische and Marie-Christine Prevost and Bernard Krust and Philippe Bouvet and Alessandro Bianco and Jacques Briand and Ara G. Hovanessian},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 23},
  pages={
          20877-86
        }
}
The multivalent pseudopeptide HB-19 that binds the cell-surface-expressed nucleolin is a potent inhibitor of human immunodeficiency virus (HIV) infection by blocking virus particle attachment and thus anchorage in the plasma membrane. We show that cross-linking of surface-bound HB-19A (like HB-19 but with a modified template) results in aggregation of HB-19A with surface nucleolin. Consistent with its specific action, HB-19A binding to different types of cells reaches saturation at… CONTINUE READING
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