The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes.

@article{Percudani2005TheAC,
  title={The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes.},
  author={Riccardo Percudani and Barbara Montanini and Simone Ottonello},
  journal={Proteins},
  year={2005},
  volume={60 4},
  pages={670-8}
}
A novel protein family homologous to the sugar-binding antiviral protein cyanovirin-N (CVN) is described. CVN, an 11-kDa protein that, by binding to the high-mannose moiety of certain viral surface glycoproteins, blocks virus entry into target cells, has thus far been identified only in the cyanobacterium Nostoc ellipsosporum. Here we show that CVN belongs to a protein family identified by analysis of transcript sequences deriving from a gene expression profiling study conducted in the truffle… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…