The anti‐inflammatory effects of cetirizine

@article{Walsh1994TheAE,
  title={The anti‐inflammatory effects of cetirizine},
  author={Garry M Walsh},
  journal={Clinical \& Experimental Allergy},
  year={1994},
  volume={24}
}
  • G. Walsh
  • Published 1994
  • Medicine
  • Clinical & Experimental Allergy
111 asthnui. numerous ^Uklu>, i ia\c prniucii lu Hû Hupni Uuicc ol itirwiiy inflaniniaiion winch w c\idcu\ c\cn ii mild iiiseasc 11 j . InthiniiiKnurH cciK ha \ c been dckvicd i pCTihronchial nssiic hiopsK^ I rom aslhriKUi;; suh^'Cls an both Hifittraung and resKkail cclK arc ihoinilu to sccrck\ar ic l \ ot b ioach\c iiicihators and cMuki[h.-\. Rcsidcin ceils i^ickidc niasl cclK. nhrohlasis d i H l i l d l Ihc innhrahi!!.^ iiiflanimaion ccH cosniophiK and IIKU'M.HHICIL';.U ceils and ! cells… Expand

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A new H1 antihistamine, cetirizine, was studied to determine its effects on mediators and cellular infiltration during the cutaneous late-phase response (LPR) and the most dramatic effect was attenuation of the inflammatory cell migration into the chamber. Expand
Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo
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The results suggest that cetirizine acts on eosinophil migration by inhibiting the release of mast cell mediators or inhibition of the eOSinophilotactic mediators themselves. Expand
Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine).
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It is confirmed that cetirizine, at therapeutical concentration, has a potent inhibitory action on eosinophil response to different chemoattractant mediators such as platelet-activating factor (PAF acether) and N-formyl methionyl leucyl phenyl alanyl in vitro. Expand
Effects of cetirizine on human eosinophil and neutrophil activation in vitro.
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The view that cetirizine may exert some of its anti-allergic effects by inhibiting the activation of human granulocytes and that it may also selectively inhibit PAF-induced eosinophil hyperadherence is supported. Expand
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Results from controlled clinical trials indicate that cetirizine is an effective and well tolerated treatment of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria, and it appears to provide a useful alternative to other 'nonsedating' antihistamines. Expand
In vivo effects of cetirizine on cutaneous reactivity and eosinophil migration induced by platelet-activating factor (PAF-acether) in man.
TLDR
Cetirizine, besides its anti-H1 effect, has the potential to modulate the allergic inflammatory response and inhibited both the immediate cutaneous response and the eosinophil influx induced by allergen and by a potent eos inophil chemotactic factor, such as PAF-acether. Expand
The effect of a single oral dose of prednisolone or cetirizine on inflammatory cells infiltrating allergen‐induced cutaneous late‐phase reactions in atopic subjects
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Findings indicate a single dose of prednisolone significantly reduces leucocyte infiltration and activation as well as the magnitude of the cutaneous late‐phase reaction. Expand
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It is demonstrated that DSCG directly inhibits the secretory properties of inflammatory cells and that in turn might have important implications in modulating mechanisms contributing to the inflammatory component of asthma and allergic disease. Expand
Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin.
TLDR
The new H1-receptor antagonist, cetirizine 2 HCl, orally administered with 10 mg once a day to pollen-sensitive patients in a double-blind, crossover study versus placebo, induced a significant decrease in the wheal-and-flare cutaneous reaction induced by intradermal injection of pollen, histamine, and compound 48/80. Expand
Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by cetirizine.
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It is confirmed that cetirizine had a potent inhibitory action in vitro on eosinophil chemotaxis induced either by N-formyl-Met-Leu-Phe or platelet-activating factor and also on the IgE-dependent stimulation of platelets. Expand
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