The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats

  title={The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats},
  author={Makoto Mizuno and Hiroki Kawamura and Yuta Ishizuka and Hidekazu Sotoyama and Hiroyuki Nawa},
  journal={Pharmacology Biochemistry and Behavior},
Abnormal signaling mediated by epidermal growth factor (EGF) or its receptor (ErbB) is implicated in the neuropathology of schizophrenia. Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge. In the present study, we assessed acute and subchronic effects of its administration on methamphetamine-triggered behavioral… Expand
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The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia
It is concluded that emodin can both attenuate EGF receptor signaling and ameliorate behavioral deficits and might be a novel class of a pro-drug for anti-psychotic medication. Expand
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