The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats

@article{Mizuno2010TheAD,
  title={The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats},
  author={Makoto Mizuno and Hiroki Kawamura and Yuta Ishizuka and Hidekazu Sotoyama and Hiroyuki Nawa},
  journal={Pharmacology Biochemistry and Behavior},
  year={2010},
  volume={97},
  pages={392-398}
}
Abnormal signaling mediated by epidermal growth factor (EGF) or its receptor (ErbB) is implicated in the neuropathology of schizophrenia. Previously, we found that the anthraquinone derivative emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits ErbB1 signaling and ameliorates behavioral deficits of the schizophrenia animal model established by EGF challenge. In the present study, we assessed acute and subchronic effects of its administration on methamphetamine-triggered behavioral… Expand
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