The anthelmintic pyrantel acts as a low efficacious agonist and an open-channel blocker of mammalian acetylcholine receptors.

@article{Rayes2001TheAP,
  title={The anthelmintic pyrantel acts as a low efficacious agonist and an open-channel blocker of mammalian acetylcholine receptors.},
  author={Diego Rayes and Mar{\'i}a Jos{\'e} De Rosa and Guillermo Spitzmaul and Cecilia Bouzat},
  journal={Neuropharmacology},
  year={2001},
  volume={41 2},
  pages={238-45}
}
Pyrantel is an anthelmintic which acts as an agonist of nicotinic receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Here we explore at the single-channel level the action of pyrantel at mammalian muscle AChR. AChR currents are elicited by pyrantel. However, openings do not appear in clearly identifiable clusters over a range of pyrantel concentrations (1-300 microM). The mean open time decreases as a function of concentration, indicating… CONTINUE READING